This thus makes JCR redundant. FASEB J (2020) 34(12):1614462. Trudel G, Shafer J, Laneuville O, Ramsay T. Characterizing the effect of exposure to microgravity on anemia: more space is worse. MITPress. Terms with >1.5 enrichment in each temporal cluster were plotted with the number of genes mapping to that specific GO term indicated in brackets. Twenty astronauts scheduled to travel to the ISS voluntarily attended a presentation of the Marrow Adipose Reaction: Red Or White (MARROW) project approximately 1 year before an astronauts scheduled flight. Following the latest release of the Web of Science Group's Journal Citation Report (JCR) and Scopus' CiteScore, we have 46 journals with a Journal Impact Factor and 57 journals with a CiteScore. We measured gene expression through RNA sequencing of leukocytes and applied generalized linear modeling to assess differential expression across all 10 time points followed by the analysis of selected time points and functional enrichment of changing genes to identify shifts in biological processes. GT and OL participated in the funding acquisition. Figure1 Experimental design. All sequence analyses and result visualizations were conducted using the R environment (https://cran.r-project.org/doc/manuals/r-release/R-intro.html) and custom scripts. Bioinformatics (2005) 21(16):343940. Please refer to the Web of Science data source to check the exact journal impact factor (Thomson Reuters) metric. In C1, seven of the top eight most enriched terms described immune system and leukocyte functions. Our study also identified additional expression changes at phase transitions in genes unrelated to specific immune functions, such as cell population regulation. Interestingly, the gene expression convergence of astronauts replicated the results of participants to the 60-day bedrest study (40), supporting that gene expression convergence is related to inactivity and redirected gravity isolated from other space specific stressors. Shown in a dot plot are the GO terms from each temporal gene cluster with an enrichment >1.5 (Figure2). :Frontiers in Immunology Frontiers in Immunology IS SN:1664-3224,2010Frontiers Media S.A 62018 4+5202020207.5618.436 JCR While the space missions were longer with an average of 6 months compared to the 60 days period in bed, the transcriptome changes at phase transition coincided. Investigators can request access to the astronaut data at jsc-lsda@mail.nasa.gov. The overall rank of Frontiers in Immunology is 1297. The NASA twins study: a multidimensional analysis of a year-long human spaceflight. The CiteScore journal impact metric measures the average citations received in a four-year time window to selected documents published in the same four years. The final, formatted version of the article will be published soon. For instance, we identified Zinc-Finger Antiviral Proteins (ZAP) ZNF776, ZNF585B, and ZNF83 as downregulated during early spaceflight and upregulated upon return to Earth. Towards human exploration of space: the THESEUS review series on immunology research priorities. A = citations in published articles in 2020 and 2021 by indexed journals during 2022. The high Impact Factor and ranking of Frontiers in Immunology reflect the quality and impact of the research published in the journal and its importance in advancing the field of immunology. Frontiers in Immunology portrays how advances of scientific knowledge and technology may translate into novel approaches to diagnosis and treat immune disorders, both in animal and cellular models and in humans. 5.9.97.208 Web A peer-reviewed open access journal in immunology adaptive immunity. doi: 10.1152/japplphysiol.00363.2020, 45. * Correspondence: Frontiers in Immunology has a current Impact Factor of 6.429, ranked 19th out of 184 journals in the Immunology category. Oncol. It is also the 1st most cited open-access journal in Immunology. March 9, 2023 This article explores the Frontiers in Immunology Impact Factors, including their significance, ranking, and trends. An opposite response occurs upon return to Earth; blood redistributes to the lower limbs, requiring an increase of total blood volume achieved by increasing fluid intake (6). Functional enrichment of the two differentially expressed gene clusters across all 10 time points produced terms describing different biological functions. Your IP: This transcriptomic response is consistent with the head ward fluid shift and subsequent hemoconcentration of blood cells occurring when entering space (38). Immunology focuses on the bodys immune system, including how it works, can manipulate, and can be harnessed to prevent or treat diseases. Colored lines, split violin, and box plots represent the profiles of temporal gene clusters identified through hierarchical clustering. The relevance of the research to the field, The rigor of the study design and methodology, The potential impact of the research on scientific knowledge and clinical practice. Other factors to consider include the following: As of the latest Journal Citation Report (JCR) released in June 2022, the Impact Factor of Frontiers in Immunology is 7.874, ranking it 19th out of 173 journals in the Immunology category. they are not paid for their role to act as Associate or Review Editors, and any award scheme is not linked to acceptances of manuscripts. Web Impact Factor. You can email the site owner to let them know you were blocked. s is the number of RNA samples with libraries that passed quality metrics and used for sequencing at each timepoint. NK cell function is impaired during long-duration spaceflight. Frontiers in Immunology Impact Factor is a metric used to measure the average number of citations per article in the journal over two years. Federica Pedrucci. Frozen blood samples were thawed at room temperature for ~15 min, and leukocytes layered on top of the gel were resuspended by gentle inversion of the tube. Frontiers There is a waiver policy for these charges. Frontiers in Immunology | About Our data from astronauts leukocytes provide additional evidence for the CD3 complex dynamic response to microgravity and changes occurring within the first few days after transitioning to and from space. Using the BenjaminiHochberg correction for multiple comparisons, p-values with false discovery rate (FDR) <0.05 were considered statistically significant. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. C1 consisted mostly of protein-coding genes (68.8%), 19.4% long non-coding RNAs (lncRNA), and 11.7% genes coding for other various RNA biotypes (Figure2). The higher the Impact Factor, the more prestigious the journal is. The reviewers are aided by an online standardized review questionnaire adopted to article types with the goal to facilitate rigorous evaluation according to objective criteria and the Frontiers Review Guidelines. In the past 9 years, this journal has recorded a range of SJR, with the highest being 3.034 in 2016 and the lowest being 2.021 in 2018. Introduction. Patel ZS, Brunstetter TJ, Tarver WJ, Whitmire AM, Zwart SR, Smith SM, et al. Diedrich A, Paranjape SY, Robertson D. Plasma and blood volume in space. It is used to ascertain the importance or rank of a journal by counting the times its articles were cited. Frontiers, a publisher of open-access scholarly journals, publish it. Brain Behav Immun [Internet] (2014) 39:2332. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public - and shape society. It considers the number of citations received by a journal and the importance of the journals from where these citations come. Knockdown of MEOX1 in Treg cells revealed a profound impact on downstream gene expression programs and Treg cell suppressive capacity. All authors participated in the acquisition, analysis, or interpretation of data. Visitors may also download and forward articles subject to the citation requirements and subject to any fees Frontiers may charge for downloading licenses. Received: 24 Nov 2022; Accepted: 27 Jun 2023. Influence of microgravity on apoptosis in cells, tissues, and other systems in vivo and in vitro. The impact factor was coined by Eugene Garfield, who founded the Institute for Scientific Information (ISI). The current Frontiers in Immunology Impact Factor is 6.429, ranked 19th out of 184 journals in the Immunology category. please visit the official website of this journal. SJR acts as an alternative to the Journal Impact Factor (or an average number of citations received in last 2 years). Search About Journals, Conferences, and Book Series, Immunology (Q1); Immunology and Allergy (Q1). Frontiers In Immunology Impact Factor A decrease in circulating red and white blood cells restores blood cell concentrations to maintain homeostasis, consistent with the downregulation of genes involved in cellular proliferation (10). Evolution of the number of total citation per document and external citation per document (i.e. The Frontiers in Immunology encompasses the following areas: For a more comprehensive understanding of its scope, check the official website of this journal. What if you could instruct a swarm of robots to paint a picture? J Appl Physiol (2016) 120(8):891903. The impact factor counts the average number of citations per article in a particular journal. Bio-type annotation was done using the biomaRt package in R environment (18, 19), which utilized the Vega archive gene classifications (https://vega.archive.ensembl.org/info/about/gene_and_transcript_types.html). This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). With an Impact Factor of 6.429, Frontiers in Immunology is the 5th most-cited Immunology journal in the world. With an Impact Factor of 5.511, Frontiers in Immunology is among the top 10 most-cited journals in its field Bioinformatics (2005) 21(10):25501. Frontiers in Immunology is composed of the following Specialty Sections: Alloimmunity and Transplantation Antigen The latest h-index of the Frontiers in Immunology is 190. Genome Res [Internet] (1971) 13(22):426. doi:10.1101/gr.1239303.metabolite, 24. The GO term cluster networks were further processed for clarity and aesthetics using Cytoscape (v3.9.1.0) (23). To our knowledge, this represents a novel finding. Associate Editors are mandated to only accept to edit a manuscript if they have no conflicts of interest (as stated here and in their review invitation and assignment emails). According to SCImago Journal Rank (SJR), this journal is ranked 2.022. WebIn this review, the dysbiosis of gut microbiota in SLE, potential mechanisms linking gut microbiota and SLE, and immune dysregulation associated with gut microbiota in SLE are summarized. Some Journals considers all the manuscripts submissions as a basis of acceptance rate computation. LRT of all 10 time points identified 276 genes differentially expressed between any time point of the study. Afshinnekoo E, Scott RT, MacKay MJ, Pariset E, Cekanaviciute E, Barker R, et al. This pattern was observed for the 276 temporally differentially expressed genes (Figure2) and was also evident with the profile of 15,410 genes obtained from independent filtering in DESeq2 (Supplementary Figure4). Frontiers Supplementary Figure4 | Expression profile of 15,410 genes expressed before, during and after long-duration spaceflight. 34. The three most represented gene families were Zinc-Finger Protein (ZNF) genes (n = 6), Cluster of Differentiation (CD) genes (n = 3), and Long Intergenic Non-Protein Coding (LINC) RNA (n = 3). Gene z-scores of temporal gene clusters were then plotted across time using lines and split violin plots overlayed by box plots to visualize the relative expression of genes over the course of the study (Figure2). doi: 10.3174/ajnr.A6249, 3. Kozaki T, Takahama M, Misawa T, Matsuura Y, Akira S, Saitoh T. Role of zinc-finger anti-viral protein in host defense against sindbis virus. Frontiers The gene AQP3 with changes in opposite directions at both phase transitions functions as a water and urea exit mechanism of antidiuresis in collecting duct cells a mechanism regulating body fluids (37). Sec. Our impact metrics reflect the power of research that is open to all. Results published in Frontiers in Psychiatry show fathers who are more involved in parenting are less likely to experience depressive symptoms. Authors are therefore free to disseminate and re-publish their articles, subject to any requirements of third-party copyright owners and subject to the original publication being fully cited. Conversely, gene C2 displayed increased expression transitioning to space and decreased expression at return to Earth (Figure2). 14:1171103. doi: 10.3389/fimmu.2023.1171103. The JCR provides quantitative tools for ranking, evaluating, categorizing, and comparing journals that are indexed on the two indexes mentioned above. RNA bio-type, gene counts, and percentages are indicated. As our understanding of the immune system and its role in health and disease continues to evolve, we expect many exciting discoveries and advancements. Principal component scores were calculated using the prcomp() function in R for all 72 samples. Frontiers in Immunologyis the official Journal of theInternational Union of Immunological Societies (IUIS). Microbial Immunology Volume 14 - 2023 | doi: 10.3389/fimmu.2023.1224102 Crosstalk between hypoxic cellular micro-environment and the immune system: a potential therapeutic target for infectious diseases Some of the latest trends and developments in immunology research include the use of gene editing technologies such as CRISPR-Cas9 to develop new treatments for genetic diseases, the use of immune checkpoint inhibitors to treat cancer, and the development of personalized immunotherapies that can be tailored to an individuals immune system. When reaching space, the transcriptomic changes are indicative of decreased immune functions and increased basic cellular activities linked to adaptive changes. ISI was acquired by Thomson Scientific & Healthcare in 1992 and was renamed Thomson ISI. Fourteen astronauts, 11 men and 3 women consented to participating in the study. Ftima Milhano Santos. Respir Physiol Neurobiol [Internet] (2009) 169(Suppl 1):S3033. The time it takes from manuscript submission to final publication. The analysis of transcriptome composition identified changes during the transitions to and from space characterized mainly by a decrease and an increase of transcript levels respectively. Ten venous blood samples were collected from each astronaut throughout the three phases of their mission: one sample at pre-flight (PF) between 90 and 60 days before liftoff, four samples in-flight (IF) onboard the ISS (IF1: between days 4 and 6; IF2: between days 8 and 12; IF3: between days 65 and 95; IF4: 30 to 1 days before returning on Earth), and five samples upon return to Earth (R) (R1: day 1; R2: between days 3 and 7; R3: between days 12 and 15; R4: between days 23 and 37; R5: between days 335 and 395). Authors retain copyright of their work and can deposit their publication in any repository.